Phendimetrazine

Similar to amphetamines, phendimetrazine increases the release of norepinephrine and dopamine from nerve terminals and inhibits their reuptake. Clinical effects include CNS stimulation and elevation of blood pressure. Appetite suppression is believed to occur through direct stimulation of the satiety center in the hypothalamic and limbic region.

Tolerance to the anorexiant effects of phendimetrazine usually develops within a few weeks of starting therapy. The mechanism of tolerance appears to be pharmacodynamic in nature; higher doses of phendimetrazine are required to produce the same response. When tolerance develops to the anorexiant effects, it is generally recommended that phendimetrazine be discontinued rather than the dose increased.

Who should not take this medication? Do not take phendimetrazine if you are pregnant or trying to become pregnant. Your health care provider needs to know if you have any of these conditions: agitation or nervousness; diabetes; glaucoma; heart disease; high blood pressure; a history of substance abuse; kidney disease; a lung disease called Primary Pulmonary Hypertension; have taken an MAOI like Eldepryl, Marplan, Nardil, or Parnate in last 14 days; thyroid disease; an unusual or allergic reaction to phendimetrazine, other medicines, foods, dyes, or preservatives; pregnant or trying to become pregnant; breast-feeding. Notify your physician immediately if you become short of breath during your normal activities. Do not take this medicine within 6 hours of bedtime; it can keep you from falling asleep.

Please discuss with your healthcare provider.

Blurred vision or other eye problems; changes in sexual ability or desire; constipation or diarrhea; difficulty sleeping; dry mouth; flushing; headache; nausea; sweating.

Call your health care provider immediately if you are experiencing any signs of chest pain, palpitations; depression or severe changes in mood; increased blood pressure; irritability; nervousness or restlessness; painful urination; severe dizziness; vomiting.

Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.